Punam Malik, MD

Cure Sickle Cell Initiative recommendations on common data elements for sickle cell disease gene therapy trials. Lanzkron, S; Coleman-Cowger, VH; Thompson, AA; Carroll, CP; Clemons, T; Debaun, M; Kanter, J; Malik, P; Manwani, D; Pierciey, FJ; Walters, MC; Alai, S. Blood advances. 2026; 10(11):3960-3965.

Renin-Angiotensin-Aldosterone System Inhibition Exacerbates Anemia in Sickle Cell Disease. Eskandari, N; Pappano, E; Ruiz, MAD; Mahmud, N; Ren, G; Ivy, ZK; Gaitonde, S; Gordeuk, VR; Gladwin, MT; Malik, P; Quinn, CT; Saraf, SL. Blood. 2026.

Angiotensin signaling is essential for stress erythropoiesis but causes retention of dysfunctional mitochondria in RBCs. Rai, P; Roy, S; Arumugam, P; Konstantinidis, DG; Ponny, SR; Eiymo Mwa Mpollo, M-S; Shrestha, A; Kalfa, TA; Malik, P. JCI Insight. 2026; 11(9).

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview. Kassim, AA; Thompson, AA; Malik, P. American Journal of Hematology. 2026; 101 Suppl 1(Suppl 1):56-74.

Longitudinal changes and predictors of cardiac extracellular volume fraction in sickle cell anemia. Niss, O; Morin, CE; Hashemi, S; Alsaied, T; Lang, SM; Taylor, MD; Tasset, M; Malik, P; Quinn, CT. Blood Red Cells Iron. 2025; 1(3).

Replicative stress-induced aging of hematopoietic stem progenitor cells increases oncogenic mutation burden and incidence of myelodysplasia in sickle cell disease mice. Chi, M; Lucas, F; Husami, A; Setayesh, T; Zhu, Z; Kaur, H; Tijani, A; Khanal, S; Chen, J; Zhang, W; Malik, P. Blood. 2025; 146(Supplement 1):11.

Renin-angiotensin-aldosterone system inhibitors exacerbate anemia in sickle cell disease. Pappano, E; Eskandari, N; Ruiz, MA; Ren, G; Zhang, X; Han, J; Ivy, Z; Njoku, F; Farooqui, M; Molokie, R; Gordeuk, V; Gladwin, M; Malik, P; Quinn, C; Saraf, S. Blood. 2025; 146(Supplement 1):297-297.

Oxidative stress and hemoglobin-c denaturation drive hemoglobin SC pathophysiology and can be ameliorated by antioxidants and hydroxyurea. Setayesh, T; Tijani, A; Kaur, H; Khanal, S; Zhu, Z; Chi, M; Kincaid, A; Ware, R; Malik, P. Blood. 2025; 146(Supplement 1):7.

Impact of disease genotype and severity of anemia on myocardial extracellular volume fraction in sickle cell disease (SCD) and non-SCD hemolytic anemias. Niss, O; Morin, C; Hashemi, S; Alsaied, T; Lang, S; Tasset, M; Taylor, M; Malik, P; Quinn, C. Blood. 2025; 146(Supplement 1):2957.

A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyurea. Setayesh, T; Chi, M; Oestreicher, Z; Sakabe, M; Seu, K; Zhu, Z; Kaur, H; Tijani, A; Xin, M; Shova, A; Balla, J; Vandenheuvel, K; Hu, Y-C; Malik, P. Blood. 2025; 146(1):13-28.